WebApr 1, 2024 · In hepatocellular carcinoma (HCC), Wnt/CTNNB1 mutations characterize the immune-excluded class (cold tumors) and might represent the biomarkers predicting resistance to immune checkpoint inhibitors. Large-scale validation of these data is needed to customize immunotherapy in advanced HCC. See related article by Harding et al., p. 2116 WebJan 3, 2024 · Abnormal activation of the Wnt/β-catenin pathway by mutations in adenomatous polyposis coli, AXIN2, or β-catenin (CTNNB1) is responsible for the …
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WebApr 11, 2024 · Wnt/Ctnnb1 signaling in podocytes plays a critical role in integrating cell adhesion, motility, cell death, and differentiation. These data reveal that beta-catenin is not required for the maintenance or differentiation of neural stem cells, but is required for the adhesion and survival of neural progenitor cells. WebAbstract. CTNNB1 mutations and aberrant β-catenin expression have adverse prognosis in endometrial endometrioid carcinoma, and recent evidence suggests a prognostic role of … canby consignment sale
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WebNon-small cell lung carcinomas with CTNNB1 (beta-catenin) mutations: A clinicopathological study of 26 cases Non-small cell lung carcinomas with CTNNB1 (beta-catenin) mutations: A clinicopathological study of 26 cases Ann Diagn Pathol. 2024 Jun;46:151522. doi: 10.1016/j.anndiagpath.2024.151522. Epub 2024 Apr 20. Authors WebSep 16, 1997 · Mutation of the β-catenin gene, CTNNB1, would result in disruption of a large number of cellular functions that may be important in tumor development. We have … WebApr 10, 2024 · Mechanistically, ME2 promotes the production of pyruvate, which directly binds to β-catenin and increases β-catenin protein levels. Notably, pyruvate treatment restores cell migration and invasion of ME2-depleted cells. Our findings provide a mechanistic understanding of the link between ME2 and cell migration and invasion. canby co op