Human perforin
WebDescription Perforin is a 70 kD cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis. Product Details Technical data sheet Product Details Isotype Control WebRecognizes natural human Perforin Incubation 2h45 Sample Type Supernatant, Buffered Solutions, Not suitable for use with serum and plasma. Sample Size 100 µl Cross Reaction No cross reactivity with Trail, TRAIL R3, TRAIL R4, Granzyme B, TNFα, IFNγ, Fas, Fas L, IL-1b, IL-2 Kit Content
Human perforin
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Web4 dec. 1996 · Human perforin: rapid enrichment by immobilized metal affinity chromatography (IMAC) for whole cell cytotoxicity assays. Perforin, a potent pore … Web1 nov. 2004 · Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells use the perforin/granzyme pathway as a major mechanism to kill pathogen-containing cells and tumor cells. 1, 2 Dysregulation of this pathway results in several human diseases, such as hemophagocytic lymphohistiocytosis.
WebView Human Perforin Antibody (MAB103853-100) datasheet. Detection of Perforin in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with (A) Mouse Anti-Human Perforin Monoclonal Antibody (Catalog # MAB103853) or (B) isotype control antibody followed by Anti-Mouse IgG Allophycocyanin … Perforin is a pore forming cytolytic protein found in the granules of cytotoxic T lymphocytes (CTLs) and natural killer cells (NK cells). Upon degranulation, perforin molecules translocate to the target cell with the help of calreticulin, which works as a chaperone protein to prevent perforin from degrading. … Meer weergeven Perforin-1 is a protein that in humans is encoded by the PRF1 gene and the Prf1 gene in mice. Meer weergeven Homozygous inheritance of defective PRF1 alleles result in the development of familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal … Meer weergeven • Granzymes • Defensin • Complement membrane attack complex Meer weergeven • perforin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Perforin-1 Meer weergeven Perforin has been shown to interact with calreticulin. Meer weergeven • Trapani JA (1996). "Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine … Meer weergeven
WebDescription. Perforin is a 70 kD cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Perforin is one … WebDescription Perforin is a 70 kD cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Perforin is one …
Web2 dagen geleden · The need for immunosuppressive drugs is one major roadblock to using pancreatic islet transplantation to treat diabetes. Hu et al. used CRISPR to knock out the genes encoding class I and II MHC and overexpress CD47 in primary human pancreatic islet cells, making them immune-evasive.The hypoimmune cells were reaggregated into …
WebPerforin and granzymes: function, dysfunction and human pathology A defining property of cytotoxic lymphocytes is their expression and regulated secretion of potent toxins, … body armor certificationWebDescription Perforin is a 70 kD cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis. Product Details Technical data sheet Product Details Isotype Control clonazepam yellow round pillsWeb22 jun. 2024 · Abcam’s Perforin (PRF1) Human in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the quantitative measurement of Perforin in … bodyarmor celebrity endorsementsWebDescription Perforin is a 70 kD cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis. Product Details Technical Data Sheet (pdf) Product Details clonbegWeb22 okt. 2008 · Anti-human perforin antibodies were purchased from Diaclone (clone B-D48, Besancon, France) and BD Biosciences (clone δG9). It should be noted that for the remainder of this article we will address the perforin clone purchased from Diaclone as “D48” so as not to cause confusion with the δG9 clone purchased from BD Biosciences. clonazolam what is itWebDescription Perforin is a 70 kD cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis. Product Details Technical data sheet Product Details Isotype Control body armor carrier and platesWeb13 apr. 2024 · In conclusion, these results indicate the perforin/granzyme pathway as the major pathway to mediate cytotoxicity in CD19-CAR-NK92 cells. Chimeric ... NK-cells … body armor ceramic plates