Pleiotropic traits

Author: yjmh

August undefined, 2024

Webb26 mars 2024 · PLACO implements a variant-level formal statistical test of pleiotropy of two traits using summary-level GWAS data, and can account for potential correlation across traits, such as that arising due to shared controls in case-control studies. The R function placo implements this pleiotropic association test Webb10 jan. 2024 · By definition, pleiotropy is a situation in which one gene controls for the expression of multiple phenotypic traits. These traits don’t have to be clearly linked, i.e., …

Pleiotropy in complex traits: challenges and strategies

WebbThe meaning of PLEIOTROPY is the phenomenon of a single gene influencing two or more distinct phenotypic traits : the quality or state of being pleiotropic. How to use pleiotropy … Webb21 mars 2024 · The genetic basis of complex traits has been thought to exhibit pleiotropy, which is the notion that a single locus can control two or more unrelated traits. … division of corporate services

Pleiotropy - Wikipedia

Webb21 feb. 2012 · In particular, these authors declared genes to have a pleiotropic effect on a trait only if the effect achieved statistical significance for that trait — the threshold was usually set high to ... In pleiotropy, one gene controls the expression of several phenotypic traits. Phenotypes are traits that are physically expressed such as color, body shape, and height. It is often difficult to detect which traits may be the result of pleitoropy unless a mutationoccurs in a gene. Because pleiotropic genes control … Visa mer An example of pleiotropy that occurs in humans is sickle cell disease. Sickle cell disorder results from the development of abnormally shaped red blood cells. Normal red blood cells have a biconcave, disc-like shape and contain … Visa mer Antagonistic pleiotropy is a theory proposed to explain how senescence, or biological aging, can be attributed to natural selection of certain pleiotropic alleles. In antagonistic … Visa mer Webb20 mars 2015 · Several recent theoretical papers based on a pleiotropic model for trait evolution suggest that it is possible that a large proportion of the genetic variance could … division of corporation indiana

Pleiotropic Definition & Meaning - Merriam-Webster

A powerful method for pleiotropic analysis under composite null

Webb26 juli 2024 · Key message Two major and stable QTLs for spike compactness and length were detected and validated in multiple genetic backgrounds and environments, and their pleiotropic effects on yield-related traits were analyzed. Abstract Spike compactness (SC) and length (SL) are greatly associated with wheat (Triticum aestivum L.) grain yield. To … WebbOne measure of pleiotropy is the fraction of genetic variance that is common between two distinct complex human traits: e.g., height vs bone density, breast cancer vs heart attack risk, or diabetes vs … division of corporation florida phone numberWebbSuch traits may even be controlled by genes located on entirely different chromosomes. Human height, eye and hair color are examples of what. Pleiotropic Traits. How can a mutation in one single gene cause a disease with a wide range of symptoms. Population genetics. the quantitative study of how gene. Breeding population. division of corporation nevada

"WebbIn fact, pleiotropic genes are responsible for a host of devastating human diseases. This page has been archived and is no longer updated Pleiotropy: One Gene Can Affect … " - Pleiotropic traits

Pleiotropic traits

Pleiotropy - an overview ScienceDirect Topics

Webb18 okt. 2024 · 52 considering particular pleiotropic paths versus systematically exploring and controlling for 53 potential pleiotropic paths via known characteristics. It is made available under a CC-BY 4.0 International license. was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. Webb1 jan. 2024 · Not only nuclear but also a mitochondrial genome can be the bearer of pleiotropic traits. In Benedictis et al. ( 1999 ), the incidence of nine haplotypes in centenarians (over 100 years old) and the control group (age 25–78 years) of men and women from northern Italy was studied.

Did you know?

Webb1 dec. 2008 · They used quantitative trait loci ... Kenney-Hunt, J. P. et al. Pleiotropic patterns of quantitative trait loci for 70 murine skeletal traits. Genetics 178, 2275–2288 (2008) WebbPleiotropy in complex traits: challenges and strategies. Genome-wide association studies have identified many variants that each affects multiple traits, particularly across …

Webb8 dec. 2024 · Author summary We propose a new approach PLACO that uses aggregate-level genotype-phenotype association statistics—commonly referred to as GWAS … Webb20 juni 2024 · The phenotype is composed of five color traits: dorsal hue, dorsal brightness, ventral color, dorsal–ventral boundary, and tail stripe. Each trait is …

Webb28 apr. 2024 · Key message A comprehensive linkage atlas for seed yield in rapeseed. Abstract Most agronomic traits of interest for crop improvement (including seed yield) are highly complex quantitative traits controlled by numerous genetic loci, which brings challenges for comprehensively capturing associated markers/genes. We propose that … WebbPleiotropy is the phenomenon where one gene controls for more than one phenotypic trait in an organism. A gene is considered to possess antagonistic pleiotropy if it controls …

Webb16 juni 2024 · The problems that arise due to pleiotropic genes are sometimes referred to as pleiotropic traits. (See Figure 1) How does a gene affect the traits of a human? The …

Webb19 nov. 2024 · The role of pleiotropic genes is diverse, but there are always multiple traits affected. An example includes the pleiotropic traits for flower color, seed coat color, and … division of corporations and commercial codeWebb28 apr. 2024 · Through trait association analysis and QTL meta-analysis, we identified a total of 525 indivisible QTL that either directly or indirectly contributed to seed yield, of … craftsman bungalow interior designWebbför 12 timmar sedan · Editors have highlighted the following attributes while ensuring the content's credibility: ... Two of the pleiotropic populations were identical to the non … division of corporations arkansasWebb13 apr. 2024 · The pleiotropic effects of meQTL.5a could contribute to variation in body size and metabolic traits, and influence CpG methylation and epigenetic aging that could have an impact on lifespan. Competing Interest Statement craftsman bungalow house plans 1920sWebb7 dec. 2024 · A human genetic disorder called Marfan syndrome is caused by a mutation in one gene, yet it affects many aspects of growth and development, including height, … division of corporation of south carolinaWebbWhen the pleiotropic gene FBN1 shows various characteristics, marfan syndrome arises. Deafness and pigmentation in cats: One specific gene is responsible for the pigmentation in cats. Due to the pleiotropic gene presence, it not only affects the pigmentation but also the hearing capacity in cats which leads to deafness and also abnormal ... division of corporations bostonWebbPleiotropy is a term used to describe the multiple organ systems affected by this condition: peripheral nervous system (neurofibromas), vasculature (renal arteries), brain (learning disabilities), endocrine (pheochromocytoma), skin (café-au-lait spots), and skeleton (dysplasias and scoliosis). Mosaicism also plays some role in NF1. craftsman bungalow landscaping